ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain . Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Met-turn expected for reprolysins, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97% amino acid identity between mouse, rat, bovine and human and 45% identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis . It also processes the 26 kDa membrane-anchored pro-tumor necrosis factor-alpha (TNF-alpha ) to the 17 kDa mature TNF-alpha. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell.

Dettagli prodotto

• Codice: AN003550P_25mg
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: ≥ 1 mg/mL
• Link: Apri link
• Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
• Isotipo: Mouse IgG1, κ
• Clonalità: Monoclonal
• Clone: 11G2
• Applicazione: FCM
• Simbolo target: CDw;ADAM;ADAM metallopeptidase domain;a disintegrin and metalloprotease domain;a disintegrin and metalloproteinase domain;disintegrin and metalloproteinase domain-containing protein;ADAM10;AD10;AD18;CD156c;CDw156;HsT18717;MADM;RAK;kuz;Kuzbanian;a disintegrin and metalloprotease domain 10;a disintegrin and metalloproteinase domain 10;ADAM metallopeptidase domain 10;CD156c antigen;disintegrin and metalloproteinase domain-containing protein 10;Kuzbanian protein homolog;Mammalian disintegrin-metalloprotease;ADAM metallopeptidase domain 10;CD156c;CDw156;HsT18717;kuz;MADM;AD 10;ADA10;ADAM 10;CD 156c;disintegrin and metalloproteinase domain containing protein 10;Drosophila;homolog of;HsT 18717;Mammalian disintegrin metalloprotease
• Area di ricerca: Cell Biology;Signal Transduction;Cancer