CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substRates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.

Codice: E-AB-F1136A_25mg | Marca: Elabscience | Confezionamento: 25mg

Specie: MouseIsotipo: Rat IgG2b, κClone: 30-F11

Recombinant Mouse CD45 protein

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Codice: E-AB-F1136A_25mg
Marca: Elabscience
Specie target: Mouse
Host: Rat
Concentrazione: ≥ 1 mg/mL
Link: Apri link
Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Isotipo: Rat IgG2b, κ
Clonalità: Monoclonal
Clone: 30-F11
Applicazione: FCM
Simbolo target: B220;CD45;CD45 antigen;CD45R;CD45R0;LCA;L-CA;LY5;protein tyrosine phosphatase;receptor type;Receptor-type tyrosine-protein phosphatase C;T200;Ly-5;Ptprc;c polypeptide;CD 45;GP180;homolog of;Leukocyte common antigen;loc;Lyt-4;OTTHUMP00000033813;OTTHUMP00000033816;OTTHUMP00000033817;OTTHUMP00000038574;Protein tyrosine phosphatase receptor type c polypeptide;protein tyrosine phosphatase;receptor type;C;receptor type C;T200 glycoprotein;T200 leukocyte common antigen

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