The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.

Dettagli prodotto

• Codice: E-AB-F1303A_5mg
• Marca: Elabscience
• Specie target: Human
• Host: Mouse
• Concentrazione: ≥ 1 mg/mL
• Link: https://www.elabscience.com/p-af/le_purified_mouse_igm,_κ_isotype_control[mm_30]-e_ab_f097830
• Stoccaggio: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
• Isotipo: Mouse IgG2b, κ
• Clonalità: Monoclonal
• Clone: 5E8
• Applicazione: FCM
• Simbolo target: CKR;B-lymphocyte antigen CD;MIP1-alpha receptor like;Differentiation antigen CD;C-C chemokine receptor type;Neural cell adhesion molecule;CMKBR;N-CAM;CC-CKR;CC CKR;CCR3;CC-CKR-3;CD193;CKR3;CMKBR3;B-lymphocyte antigen CD19;C-C chemokine receptor type 3;CC CKR3;CCR;Cd19;Differentiation antigen CD19;eotaxin receptor;MIP1-alpha receptor like-2;NCAM;NCAM1;NCAM-1;N-CAM-1;Neural cell adhesion molecule 1;C-C CKR-3;C-C motif chemokine receptor 3;CD_antigen: CD193;cluster of differentiation 193;Eosinophil eotaxin receptor
• Area di ricerca: Immunology;Signal Transduction