Ubiquitin-like modifier involved in formation of autophagosomal vacuoles. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. In response to cellular stress and upon mitochondria fission, binds C-18 ceramides and anchors autophagolysosomes to outer mitochondrial membranes to eliminate damaged mitochondria. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Dettagli prodotto

• Codice: PDEH100897_1mg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from sterile PBS, pH 7.4.<br/>Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: MLP3B;MAP1LC3B
• Ig target: ATG8F;Autophagy related protein LC3 A;Autophagy related ubiquitin like modifier LC3 A;Autophagy related ubiquitin like modifier LC3 B;LC3;MAP1 light chain 3 like protein 1;MAP1 light chain 3 like protein 2;MAP1A/1B light chain 3 A;MAP1A/1BLC3;MAP1AL;MLP3B
• Area di ricerca: Signal Transduction;Cardiovascular;Cancer;Neuroscience;Metabolism