May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.

Dettagli prodotto

• Codice: PDEH100898_1mg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from sterile PBS, pH 7.4.<br/>Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: P21
• Ig target: CAP20;CDK-interacting protein 1;CDKI;CDKN1;CDKN1A;CDN1A;CIP1;Cyclin Dependent Kinase Inhibitor 1A;DNA Synthesis Inhibitor;MDA-6;MDA6;Melanoma differentiation-associated protein 6;P21cip1;P21waf;PIC1;SDI1;SLC12A9;WAF1
• Area di ricerca: Signal Transduction;Cancer;Epigenetics and Nuclear Signaling;Cell Biology