BMPs belong to the TGF-β superfamily, which currently has over 20 members. BMPs play a vital role in several processes, such as embryogenesis and tissue homeostasis; thus, they are also known as body morphogenetic proteins.9 BMP2, BMP6 and BMP7 are deeply involved in inflammatory disorders, including fibrosis, inflammatory bowel disease, ankylosing spondylitis, and rheumatoid arthritis. BMP9 is considered a unique member of the BMP family as it has the strongest osteogenic effect on mesenchymal stem cells (MSCs), is resistant to the BMP signaling inhibitors, noggin and BMP3,nd significantly affects vascular homeostasis, angiogenesis, metabolism, neurogenesis, and pro- or anti-tumorigenesis.
Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Simbolo target: GDF2
Ig target: Bone morphogenetic protein 9;BMP-9;Growth/differentiation factor 2
Area di ricerca:Developmental Biology;Cardiovascular;Signal Transduction
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