nsulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mouse IGF-I is synthesized as two precursor isoforms with alternate N-and C-terminal propeptides. These isoforms are differentially expressed by various tissues. Mature mouse IGF-I shares 94% and 99% aa sequence identity with human and rat IGF-I, respectively, and exhibits cross-species activity. It shares 60% aa sequence identity with mature mouse IGF-II. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors.

Codice: PDEM100305_100μg | Marca: Elabscience | Confezionamento: 100μg

Specie: mouse

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Codice: PDEM100305_100μg
Marca: Elabscience
Specie target: mouse
Host: E.coli
Confezionamento: Lyophilized from sterile PBS, pH 7.4.<br/>Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
Link: https://www.elabscience.com/p-recombinant_mouse_igf1/igf‑i/igf_1_protein_(his_tag)-pdem100305
Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Simbolo target: IGF1;IGF-1
Ig target: IGF-1;IGF1;Insulin-like growth factor I;Somatomedin C;insulin-like growth factor 1;somatomedin-C
Area di ricerca: Cancer;Developmental Biology;Neuroscience;Signal Transduction;Stem Cells;Metabolism

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