CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.

Codice: PDER100114_100μg | Marca: Elabscience | Confezionamento: 100μg

Specie: Rat

Torna alla lista Apri link

Codice: PDER100114_100μg
Marca: Elabscience
Specie target: Rat
Host: E.coli
Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Link: Apri link
Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Simbolo target: MCP-1
Ig target: CCL2;GDCF-2;HC11;HSMCR30;MCAF;MCP1;SCYA2;SMC-CF;
Area di ricerca: Cancer;Cardiovascular;Metabolism;Immunology

Scheda prodotto