CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.

Dettagli prodotto

• Codice: PDMR100044_1mg
• Marca: Elabscience
• Specie target: Rat
• Host: Mammalian
• Confezionamento: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: Cd86
• Ig target: Activation B7-2 antigen 3;Activation B7-2 antigen;B-lymphocyte activation antigen B7-2 2;B-lymphocyte activation antigen B7-2;B7 2;B7;B7-2;B7.2;B70;B72 antigen;BU63;CD28 antigen ligand 2 2;CD28 antigen ligand 2;Cd28l2;CD28LG2;CD86;CD86 antigen;CD86 antigen;CD86 molecule;CD86;CLS1;CTLA-4 counter-receptor B7.2 2;3;CTLA-4 counter-receptor B7.2;Early T-cell costimulatory molecule 1;ETC-1;FUN 1;FUN-1;LAB72;Ly-58;Ly58;MB7;MB7-2;Membrane glycoprotein;MGC34413;T-lymphocyte activation antigen CD86;TS/A-2
• Area di ricerca: Cancer;Immunology;Microbiology;Stem Cells