Interleukin 8 (IL-8), also known as CXCL8, which is a chemokine with a defining CXC amino acid motif that was initially characterized for its leukocyte chemotactic activity, is now known to possess tumorigenic and proangiogenic properties as well. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli. In human gliomas, IL-8 is expressed and secreted at high levels both in vitro and in vivo, and recent experiments suggest it is critical to glial tumor neovascularity and progression. Levels of IL-8 correlate with histologic grade in glial neoplasms, and the most malignant form, glioblastoma, shows the highest expression in pseudopalisading cells around necrosis, suggesting that hypoxia/anoxia may stimulate expression. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental chang. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil-mediated acute inflammation due to its potent actions on neutrophils. The discovery of these biological functions suggests that IL-8/CXCL8 has crucial roles in various pathological conditions such as chronic inflammation and cancer.

Dettagli prodotto

• Codice: PKSH030277_20μg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from sterile PBS, pH 7.4 <br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: IL-8/CXCL8
• Ig target: CXCL;Interleukin;C-X-C motif chemokine;Chemokine (C-X-C motif) ligand;IL8/CXCL;GCP;NAP;CXCL8;GCP-1;GCP1;IL8;LECT;LUCT;LYNAP;MDNCF;MONAP;NAF;NAP-1;NAP1;3-10C;AMCF-I;IL8/CXCL8;K60;Interleukin-8;IL-8;Emoctakin;C-X-C motif chemokine 8;Chemokine (C-X-C motif) ligand 8;Granulocyte chemotactic protein 1 (GCP-1);Monocyte-derived neutrophil chemotactic factor (MDNCF);(Ala-IL-8)77;(Ser-IL-8)72;9E3;Beta thromboglobulin like protein;CEF-4;chemokine;CXC motif;GCP/IL-8 protein I;GCP/IL-8 protein II;GCP/IL-8 protein III;GCP/IL-8 protein IV;GCP/IL-8 protein V;GCP/IL-8 protein VI;Granulocyte chemotactic protein 1;IL-8(1-77);IL-8(9-77);IL8/NAP1 form I;IL8/NAP1 form II;IL8/NAP1 form III;IL8/NAP1 form IV;IL8/NAP1 form V;IL8/NAP1 form VI;Inteleukin 8;ligand 8;Lymphocyte-derived neutrophil-activating factor;MDNCF-b;MDNCF-c;Monocyte-derived neutrophil chemotactic factor;Monocyte-derived neutrophil-activating peptide;Neutrophil activating peptide 1;Neutrophil activating protein 1;Neutrophil-activating factor;Neutrophil-activating protein 1;Protein 3 10C;Protein 3-10C;SCYB8;Small inducible cytokine subfamily B member 8;T cell chemotactic factor;T-cell chemotactic factor;TSG1
• Area di ricerca: Cardiovascular;Cancer;immunology