CBL proteins, such as Cbl-c, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling. Cbl-c is a member of the Cbl family of E3 ubiquitin ligases. Expression of Cbl-c gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for Cbl-c gene.

Dettagli prodotto

• Codice: PKSH030531_100μg
• Marca: Elabscience
• Specie target: Human
• Host: Baculovirus-Insect Cells
• Confezionamento: Lyophilized from sterile 20mM Tris, 500mM Nacl, 10% glycerol, pH 8.0 <br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Ig target: CBL-3;CBL-SL;RNF57
• Area di ricerca: Epigenetics and Nuclear Signaling Cancer