Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.

Codice: PKSH030730_50μg | Marca: Elabscience | Confezionamento: 50μg

Specie: Human

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Codice: PKSH030730_50μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.5<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
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Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Applicazione: Enzyme
Ig target: DAP1;GAP-Modifying Protein 1;GMP1;OFC10;SENP2;SMT3;SMT3 Homolog 3;SMT3C;SMT3H3;SUMO-1;SUMO1;Sentrin;Small Ubiquitin-Related Modifier 1;Smt3C;UBL1;Ubiquitin-Homology Domain Protein PIC1;Ubiquitin-Like Protein;Ubiquitin-Like Protein SMT3C

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