SLAM family member 6; also known as Activating NK receptor; NK-T-B-antigen; NTB-A; SLAMF6; KALI and Ly108; is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK); T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and; upon phosphorylation; with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Codice: PKSH030960_100μg | Marca: Elabscience | Confezionamento: 100μg

Specie: Human

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Codice: PKSH030960_100μg
Marca: Elabscience
Specie target: Human
Host: HEK293 Cells
Confezionamento: Lyophilized from sterile PBS, pH 7.4 <br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
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Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Ig target: Activating NK Receptor;CD352;KALI;Ly108;NK-T-B-Antigen;NTB-A;NTBA;SF2000;SLAM Family Member 6;SLAMF6
Area di ricerca: Immunology

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