Ubiquitin-conjugating enzyme E2 D1 (UBE2D1); a member of human E2 ubiquitin-conjugating enzymes; is closely related to SFT; which is short for stimulator of iron (Fe) transport. In other words; UbcH5A is significantly up-regulated in the liver of iron-overloaded patients with hereditary hemochromatosis; as previously published for SFT. Moreover; a complex of UBE2D1 is critical in maintaining KRAS protein stability and propose that targeting such complex may be a unique strategy to degrade mutant KRAS to kill cancer cells.

Dettagli prodotto

• Codice: PKSH031122_100μg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from sterile 25mM Tris, 100mM NaCl, 20% glycerol, 0.05% Tween <br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Ig target: SFT;Stimulator of Fe transport;UBC4/5 homolog;UBC5A;UBCH5;UBCH5A;UbcH5;Ubiquitin carrier protein D1;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2(17)KB 1;Ubiquitin-conjugating enzyme E2-17 kDa 1;Ubiquitin-protein ligase D1
• Area di ricerca: Cell biology;epigenetics and nuclear signal