MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of O6-methylguanine in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. MGMT catalyzes the chemical reaction: DNA (containing 6-O-methylguanine) and proteinL-cysteine into DNA (without 6-O-methylguanine) and protein S-methyl-L-cysteine.

Codice: PKSH032031_50μg | Marca: Elabscience | Confezionamento: 50μg

Specie: Human

Torna alla lista Apri link

Codice: PKSH032031_50μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl,1mM DTT,1mM EDTA,500mM NaCl,0.1%Trition X-100,pH 8.0.
Link: Apri link
Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Simbolo target: MGMT
Ig target: 6-O-methylguanine-DNAmethyltransferase;MGMT;Methylated-DNA--protein-cysteine methyltransferase;O-6-methylguanine-DNA-alkyltransferase
Area di ricerca: epigenetics and nuclear signal

Scheda prodotto