Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol). In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.

Codice: PKSH032056_50μg | Marca: Elabscience | Confezionamento: 50μg

Specie: Human

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Codice: PKSH032056_50μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Link: Apri link
Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Simbolo target: AKR1C4
Ig target: 3-Alpha-HSD1;3-Alpha-Hydroxysteroid Dehydrogenase Type I;AKR1C4;Aldo-Keto Reductase Family 1 Member C4;CDR;CHDR;Chlordecone Reductase;DD-4;DD4;Dihydrodiol Dehydrogenase 4;HAKRA
Area di ricerca: Signal Transduction;Cancer;metabolism;

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