Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases; APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors; such as c-Jun; c-Fos; NF-kB; p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

Codice: PKSH032090_50μg | Marca: Elabscience | Confezionamento: 50μg

Specie: Human

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Codice: PKSH032090_50μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Supplied as a 0.2 μm filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Link: Apri link
Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Simbolo target: APE1;APE
Ig target: AP Endonuclease 1;APE;APE-1REF-1;APE1;APEN;APEX;APEX Nuclease;APEX1;APX;Apurinic-Apyrimidinic Endonuclease 1;DNA-(Apurinic or Apyrimidinic Site) Lyase;HAP1;REF1;Redox Factor-1
Area di ricerca: Cardiovascular;epigenetics and nuclear signal

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