Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma.

Codice: PKSH032809_10μg | Marca: Elabscience | Confezionamento: 10μg

Specie: Human

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Codice: PKSH032809_10μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, pH 8.5.
Link: Apri link
Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Simbolo target: N-Glycosylase;OGG1
Ig target: 8-Oxoguanine DNA Glycosylase;AP Lyase;DNA-(Apurinic or Apyrimidinic Site) Lyase;MMH;MUTM;N-Glycosylase/DNA Lyase;OGG1;OGH1
Area di ricerca: Cancer;epigenetics and nuclear signal

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