Pyruvate Kinase Isozymes R/L (PKLR) belongs to the pyruvate kinase family, There are 4 isozymes of pyruvate kinase in mammals: L, R, M1 and M2. L type is major isozyme in the liver; R is found in red cells; M1 is the main form in muscle, heart and brain; M2 is found in early fetal tissues. PKLR exists as a homotetramer and catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in PKLR are also the cause of pyruvate kinase deficiency of red cells, which is a frequent cause of hereditary non-spherocytic hemolytic anemia.

Dettagli prodotto

• Codice: PKSH032984_10μg
• Marca: Elabscience
• Specie target: Human
• Host: HEK293 Cells
• Confezionamento: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 5% Trehalose, 5% Mannitol, 0.02% Tween 80, 50% Glycerol, 1mM EDTA, 1mM DTT, pH8.0.
• Link: Apri link
• Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
• Simbolo target: PKLR
• Ig target: PK1;PKL;PKLR;Pyruvate Kinase 1;Pyruvate Kinase Isozymes R/L;R-Type/L-Type Pyruvate Kinase;Red Cell/Liver Pyruvate Kinase
• Area di ricerca: Signal Transduction;Cardiovascular;Cancer;epigenetics and nuclear signal;metabolism;