Human Natriuretic peptides B acts as a cardiac hormone; it is associated with many biological actions; such as diuresis; natriuresis; vasorelaxation; which inhibits the secretion of rennin and aldosterone. It acts as a paracrine antifibrotic factor in the heart. Natriuretic peptides B can help restore the body balance of salt and water; improves the heart function. Natriuretic peptides B binds and stimulates the cGMP production of the NPR1 receptor and binds the clearance receptor NPR3.