Interleukin-10 Receptor alpha (IL-10Rα) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 Rα consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 Rα shares 59% aa sequence identity with mouse and rat IL-10Rα. IL-10 Rα is required for mediating the effects of IL-10,a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10Rα is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 Rα, resulting in the recruitment of IL-10 Rβ. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 Rα may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.

Dettagli prodotto

• Codice: PKSH033632_10μg
• Marca: Elabscience
• Specie target: Human
• Host: HEK293 Cells
• Confezionamento: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: https://www.elabscience.com/p-recombinant_human_il10_ra/il_10_rα_protein_(his_tag)-pksh033632
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: IL10-RA;IL-10 Rα
• Ig target: IL-10R subunit;Interleukin-10 receptor subunit;IL-10R;IL10RA;CD210;CD210a;CDW210A;HIL-10R;IL-10R1;IL10R;IL-10 receptor subunit alpha;IL-10R subunit 1;IL-10R subunit alpha;IL-10RA;Interleukin-10 receptor subunit 1;Interleukin-10 receptor subunit alpha; IL-10R1; IL-10Ra;CDw210a antigen;HIL 10R;HIL10R;I10R1;IL 10R;IL 10R 1;IL 10R A;IL 10R1;IL10R1;Interleukin 10 receptor alpha;Interleukin 10 receptor alpha chain
• Area di ricerca: immunology