Growth Arrest and DNA Damage-Inducible Protein GADD45 α (GADD45A) is a member of the GADD45 family. GADD45A can be induced by UV irradiation; X-rays; growth arrest and alkylating agents; of which can be mediated by some kinases other than PKC. GADD45A can interact with MAPK14; GADD45GIP1; PCNA. In T-cells; GADD45A functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity. GADD45A may affect PCNA interaction with some cell division protein kinase complexes; stimulating DNA excision repair in vitro and inhibits entry of cells into S phase.

Dettagli prodotto

• Codice: PKSH033661_10μg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Simbolo target: GADD45A;DDIT-1
• Ig target: DDIT-1;DDIT1;DNA Damage-Inducible Transcript 1 Protein;GADD45;GADD45A;Growth Arrest and DNA Damage-Inducible Protein GADD45 Alpha
• Area di ricerca: epigenetics and nuclear signal