The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

Dettagli prodotto

• Codice: PKSH033722_10μg
• Marca: Elabscience
• Specie target: Human
• Host: HEK293 Cells
• Confezionamento: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Applicazione: BLI
• Simbolo target: CD86;B7-2
• Ig target: LAB;ETC;FUN;CTLA-4 Counter-Receptor B;Early T-cell costimulatory molecule;CD28LG;B7-2;B7.2;B70;CD28LG2;LAB72;CD86;Activation B7-2 antigen;BU63;CTLA-4 Counter-Receptor B7.2;Early T-cell costimulatory molecule 1;ETC-1;FUN-1;T-lymphocyte activation antigen CD86; B7-2;Activation B7-2 antigen 3;B7 2;B72 antigen;B-lymphocyte activation antigen B7-2;B-lymphocyte activation antigen B7-2 2;CD28 antigen ligand 2;CD28 antigen ligand 2 2;Cd28l2;CD86 antigen;CD86 molecule;CLS1;CTLA-4 counter-receptor B7.2 2;FUN 1;Ly58;Ly-58;MB7;MB7-2;Membrane glycoprotein;MGC34413;TS/A-2
• Area di ricerca: Microbiology;immunology;Stem cells