Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.

Codice: PKSH033781_50μg | Marca: Elabscience | Confezionamento: 50μg

Specie: Human

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Codice: PKSH033781_50μg
Marca: Elabscience
Specie target: Human
Host: E.coli
Confezionamento: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Link: Apri link
Stoccaggio: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Simbolo target: ASXL1
Ig target: ASXL1;Additional sex combs-like protein 1;KIAA0978;Putative Polycomb group protein ASXL1
Area di ricerca: Signal Transduction;epigenetics and nuclear signal;

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