CD123; also known as Interleukin-3 receptor subunit alpha; belongs to the type I cytokine receptor family. In mouse; there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit does not bind IL-3 by itself but is required for the high affinity binding of IL-3 to the heterodimeric receptor complex.

Dettagli prodotto

• Codice: PKSH033800_100μg
• Marca: Elabscience
• Specie target: Human
• Host: HEK293 Cells
• Confezionamento: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Coniugazione: Biotinylated
• Simbolo target: IL3RA;CD123
• Ig target: IL3RA;CD123;IL3R;IL3RAY;IL3RX;IL3RY;hIL-3Ra;IL-3 Receptor alpha;IL-3 receptor subunit alpha;IL-3R subunit alpha;IL-3R subunitalpha;IL-3RA;IL-3R-alpha;IL-3Receptoralpha;IL-3Rα;IL-4Receptoralpha;IL-5Receptoralpha;IL-6Receptoralpha;IL-7Receptoralpha;Interleukin-3 receptor subunit alpha;IL-3R&alpha
• Area di ricerca: Signal Transduction;immunology;