Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. Importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

Dettagli prodotto

• Codice: PKSH033873_100μg
• Marca: Elabscience
• Specie target: Human
• Host: E.coli
• Confezionamento: Lyophilized from sterile PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
• Link: Apri link
• Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
• Applicazione: Cell culture
• Simbolo target: IL-36A;IL-36 alpha
• Ig target: FIL;IL1F;Interleukin-1 Family Member;IL-1F;IL36A;FIL1;FIL1(EPSILON);FIL1E;IL-1F6;IL1(EPSILON);IL1F6;FIL1 Epsilon;IL-1 Epsilon;Interleukin-1 Epsilon;Interleukin-1 Family Member 6;Interleukin-36 Alpha;IL1E;IL 1 epsilon;IL 1F6;IL 1H1;IL1RP2;Interleukin 1 epsilon;Interleukin 1 family member 6;Interleukin 1 family member 6 (epsilon);Interleukin 36 alpha;MGC129552;MGC129553;MGC151479;MGC151481;OTTMUSP00000012798;RP23-176J12.4
• Area di ricerca: immunology