CD64, also known as Fc-gamma receptor 1 (FcγRI), is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-type used to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. It is normally expressed on the surfaces of monocytes and macrophages.

Codice: PKSM041015_50μg | Marca: Elabscience | Confezionamento: 50μg

Specie: Mouse

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Codice: PKSM041015_50μg
Marca: Elabscience
Specie target: Mouse
Host: HEK293 Cells
Confezionamento: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
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Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Simbolo target: CD64;FCGR1
Ig target: CD64;Fc-gamma RI;FcRI;FcgammaRI;High affinity immunoglobulin gamma Fc receptor I;IGGHAFC;IgG Fc receptor I

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