Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO--terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.

Codice: PKSQ050096_10μg | Marca: Elabscience | Confezionamento: 10μg

Specie: Cynomolgus macaques

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Codice: PKSQ050096_10μg
Marca: Elabscience
Specie target: Cynomolgus macaques
Host: HEK293 Cells
Confezionamento: Lyophilized from a 0.2 μm filtered solution of PBS, 150mMNaCl, 0.3% Chaps, 5% Trehalose, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
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Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Applicazione: BLI
Simbolo target: Siglec-15;CD33L3
Ig target: 425O18-1;Angiopoietin-like protein 4;Angiopoietin-related protein 4;Angptl4;Farp;Fasting-induced adipose factor;Fiaf;HFARP;Hepatic fibrinogen/angiopoietin-related protein;Ng27;Secreted protein Bk89

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