Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

Codice: PKSQ050105_10μg | Marca: Elabscience | Confezionamento: 10μg

Specie: Cynomolgus macaques

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Codice: PKSQ050105_10μg
Marca: Elabscience
Specie target: Cynomolgus macaques
Host: HEK293 Cells
Confezionamento: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.<br/>Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.<br/>Please refer to the specific buffer information in the printed manual.
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Stoccaggio: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Applicazione: BLI
Simbolo target: SIRPA;CD172a
Ig target: Bit;Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs;CD172 Antigen-Like Family Member A;Inhibitory Feceptor SHPS-1;Macrophage Fusion Receptor;MyD-1 Antigen;SHP Substrate 1;SHPS-1;Signa;Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1

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