The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.

Dettagli prodotto

• Codice: E-AB-13732_20μL
• Marca: Elabscience
• Specie target: Human
• Host: Rabbit
• Concentrazione: 0.7 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:30-1:150
• Simbolo target: TRIM25
• Ig target: E3 ubiquitin/ISG15 ligase TRIM25;EFP;Estrogen responsive finger protein;Estrogen-responsive finger protein;RING finger protein 147;RNF 147;RNF147;TRI25;TRI25;TRIM 25;Trim25;Tripartite motif containing 25;Tripartite motif containing protein 25;Tripartite motif protein TRIM25;Tripartite motif-containing protein 25;Tripartite motifcontaining25;Ubiquitin/ISG15-conjugating enzyme TRIM25;Z147;Zinc finger protein 147 (estrogen responsive finger protein);Zinc finger protein 147;Zinc finger protein-147;ZNF 147;ZNF147
• Area di ricerca: Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Signal Transduction