TRPC4AP (transient receptor potential cation channel, subfamily C, member 4 associated protein), also known as TRUSS or TRRP4AP, is a 797 amino acid protein that is expressed in a variety of tissues, with highest expression in liver, heart, testis and brain. Thought to function as a scaffolding protein, TRPC4AP interacts with TNF-R1 and may both link TNF-R1 to the IKK signalsome complex, and participate in the activation of NFκB p50, an event that occurs in response to TNF-R1 ligation. TRPC4AP exists as multiple alternatively spliced isoforms that are encoded by a gene whicHuman, Mouseaps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome.

Dettagli prodotto

• Codice: E-AB-17161_60μL
• Marca: Elabscience
• Specie target: Human;Mouse
• Host: Rabbit
• Concentrazione: 0.9 mg/mL
• Link: Apri link
• Stoccaggio: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.
• Isotipo: IgG
• Clonalità: Polyclonal
• Coniugazione: Unconjugated
• Applicazione: IHC
• Diluizione: IHC 1:30-150
• Simbolo target: TRPC4AP
• Ig target: C20orf188; TRPC4AP;Chromosome 20 open reading frame 188;Protein TAP1;Protein TRUSS;Short transient receptor potential channel 4 associated protein;Short transient receptor potential channel 4-associated protein;TAP1 protein;TNF receptor ubiquitous scaffolding/signaling protein;TNF-receptor ubiquitous scaffolding/signaling protein;TP4AP;Transient receptor potential cation channel;subfamily C;member 4 associated protein;Trp4 associated protein;Trp4-associated protein;Trpc4 associated protein;Trpc4-associated protein;TRPC4AP;TRRP4AP;TRUSS;Tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein
• Area di ricerca: Epigenetics and Nuclear Signaling;Signal transduction