Alpha-fetoprotein (AFP) is a glycoprotein normally expressed in the fetal liver and yolk sac endoderm. It can be used to label hepatocellular carcinoma and a variety of germ cell tumors, such as yolk sac tumors of the testis and ovary. In the diagnosis of hepatocellular carcinoma, the sensitivity of AFP is low, but the specificity is high, so it can be used in combination with other antibodies in the diagnosis of hepatocellular carcinoma.
Alpha-fetoprotein (AFP) is a glycoprotein that is normally expressed in fetal liver and yolk sac endoderm. It can be used to mark hepatocellular carcinoma and a variety of germ cell tumors, such as yolk sac tumors of testis and ovaries. In the diagnosis of hepatocellular carcinoma, AFP has low sensitivity but high specificity, so it can be used in combination with other antibodies in the diagnosis of hepatocellular carcinoma.
ALK (Anaplastic Lymphoma Kinase, cd246) is a transmembrane receptor of leucine kinase with molecular weight about 200 kDa. ALK gene was found in CD30 + anaplastic large cell lymphoma cases in 1980. If there is genetic translocation, tumor cells will produce a kind of NPM-ALK heterozygous protein (also known as p80). In normal tissues, a few cells express ALK, such as glial cells, neurons and so on. In tumor cases, literature has shown that ALK is expressed in anaplastic large cell lymphoma, inflammatory myofibroblastic tumor, rhabdomyosarcoma, leiomyoma and lung adenocarcinoma.
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