GATA binding protein 3 (GATA3) is a member of the GATA family of transcription factors (including six members: GATA-1 to GATA-6). It plays an important role in promoting and guiding cell proliferation, development and differentiation in many tissues and cell types. GATA-3 is widely expressed in the epithelial cells of mammary duct glandular cavity and urinary tract epithelium, but not in myoepithelial cells. The expression of GATA-3 is closely associated with the expression of estrogen receptor-α in breast cancer,and there is evidence that GATA-3 can be used to predict the response to hormone therapy in breast cancer patients, and has also been shown to be a new marker for bladder cancer.
GCDFP-15 is expressed in the cytoplasm of parietal epithelium, lacrimal gland, cerumen gland, Moll's gland, mandible gland, tracheobronchial gland, sublingual gland and small salivary gland. GCDFP-15 can be used to judge breast cancer, salivary duct cancer and apical secretory epithelium.
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