Mucin 5AC (MUC5AC) is a group of high molecular weight glycoproteins, and its synthesis and secretion is one of the characteristics of glandular epithelial tissue. MUC5AC is normally expressed in gastric, ovarian, bronchial and other tissues, and forms a gel on the mucosal surface to protect the mucosa. MUC5AC protein expression can be observed in precancerous or cancerous tissues of colon, stomach, gallbladder and non-small cell lung cancer.
Mucin 6 (MUC6), also known as gastric mucus, is one of the secreted mucins produced by many different epithelial tissues. MUC6 is frequently expressed in non-neoplastic gastric tissues, especially in pyloric glands. Under physiological conditions, MUC2 is only expressed in normal intestinal mucosa (intestinal type mucus), while MUC5AC and MUC6 are only expressed in normal gastric mucosa (gastric type mucus). Therefore, the combination of these three markers has certain significance in the differential diagnosis of gastrointestinal tumors.
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