Napsin is a kind of gastric enzyme like aspartate protease. There are two related Napsin: Napsin A and Napsin B. Napsin A is a single chain protein with molecular weight close to 38 kDa.It is highly expressed in human lung and kidney, but low in spleen. Napsin A is expressed lung type II epithelium and lung adenocarcinoma. The expression sensitivity of Napsin A in lung adenocarcinoma is significantly higher than SP-A and SP-B, and it has very high specificity. In some cases of poorly differentiated lung adenocarcinoma without TTF-1, but Napsin A is expressed.Napsin A Monoclonal is recommended to be used in combination with TTF-1 for the differentiation of primary lung adenocarcinoma and other tissue-derived adenocarcinoma.
N-cadherin is mainly expressed in nerve cells, endothelial cells, muscle cells and early hematopoietic stem cells. In addition, it is expressed in a variety of tumors such as mesothelioma, chordoma, synovial sarcoma, malignant melanoma, epithelioid sarcoma, epithelioid angiosarcoma, endometrial tumor and serous tumor of ovary. It can be used to distinguish mesothelioma from adenocarcinoma.
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