Prostate-Specific Membrane Antigen(PSMA) is a 110kDa type II transmembrane protein. The gene is located at 11q, which is highly expressed in the normal and malignant prostate secretory acinar epithelium, and also in some benign epithelial cells of breast, duodenum and kidney. At present, PSMA is considered to be a specific marker of prostate cancer.
Parathyroid hormone (PTH) is a basic single-chain polypeptide hormone secreted by chief cells of parathyroid glands. Its main function is to regulate the metabolism of calcium in the body, promote the increase of blood calcium level and the decrease of blood phosphorus level. At the same time, it also acts on the intestine and renal tubules to increase the absorption of calcium, thus maintaining the stability of blood calcium. It is commonly used in the diagnosis and research of parathyroid tumors.
Nucleoside diphosphate reductase large subunit (RRM1) is one of two distinct subunits that comprise nucleoside diphosphate reductase. This enzyme is essential for the production of deoxyribonucleotides prior to S-phase DNA synthesis in dividing cells. RRM1 may reflect carcinogenesis and tumor progression. RRM1 expression is highly correlated with ERCC and PTEN expression in non-small cell lung cancer. Rrm1-positive tumors predicted slow progression.
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