Nucleoside diphosphate reductase large subunit (RRM1) is one of two distinct subunits that comprise nucleoside diphosphate reductase. This enzyme is essential for the production of deoxyribonucleotides prior to S-phase DNA synthesis in dividing cells. RRM1 may reflect carcinogenesis and tumor progression. RRM1 expression is highly correlated with ERCC and PTEN expression in non-small cell lung cancer. Rrm1-positive tumors predicted slow progression.
S-100A4 protein is an important member of S100 family. As an angiogenic factor, S-100A4 protein can enhance the mobility of endothelial cells, reduce the production of angiogenesis inhibitors, and promote the development of blood vessels, tumor invasion and metastasis.
S-100 is a soluble acidic protein. There are three subtypes, namely s-100ao, s-100a and s-100b. S-100 mainly exists in nervous tissue, pituitary, carotid body, adrenal medulla, salivary glands, and few interlobular tissues, S-100 is mainly used to diagnose the astrocytoma oligodendroglioma, ependymoma, neuroblastoma, schwannoma, malignant melanoma and liposarcoma.
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