A synthesized peptide derived from human NDRG3, corresponding to a region within the internal amino acids.
The N-myc downstream regulated gene (NDRG) family is comprised of four members, NDRG1 (also designated Drg1, RTP, rit42, Cap43 and Ndr1), NDRG2, NDRG3 and NDRG4, which share 57-65% homology. The gene encoding NDRG3 maps to human chromosome 20q11 and is predominantly expressed in testis, prostate and ovary, which suggests it may play a role in spermatogenesis.
NDRG3belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function ofNDRG3and its relationship to cancer has not been studied.NDRG3 expression is enriched in testis and prostate using gene expression data derived from massively parallel signature sequencing from 33 different human organs. NDRG3 is also expressed in both epithelial prostate cancer cells and prostatic stromal cells at both mRNA and proteins levels.
A synthesized peptide derived from human NDRG4, corresponding to a region within the internal amino acids.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.
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