The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).
A synthesized peptide derived from human NME5, corresponding to a region within C-terminal amino acids.
TheNME5gene encodes a 212-amino acid polypeptide with homology to the NDP kinases. Northern blot analysis detected abundant expression of a 1.1-kb mRNA in testis. In situ hybridization to testis revealedNME5mRNA in the seminiferous tubules in a pattern consistent with stage-specific expression in germinal cells during spermatogenesis.
Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.
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