This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. Arc has been shown to localize to the cytoskeleton of neuronal cells and appears to colocalize with F-Actin, although it may associate with an Actin-associated protein rather than directly with F-Actin. It has been shown that cocaine-stimulated neuronal activity results in increased Arc mRNA levels in striatum.
A synthesized peptide derived from human NOL4, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NOL6.
A synthesized peptide derived from human NOL7, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human NOL8, corresponding to a region within C-terminal amino acids.
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth. Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
A synthesized peptide derived from human NOL9, corresponding to a region within the internal amino acids.
Nucleolar protein 9is aproteinthat in humans is encoded by theNOL9gene. Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.
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