The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs).
A synthesized peptide derived from Human NSP3.
A synthesized peptide derived from human NSUN2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NSUN5.
A synthesized peptide derived from human NSUN6.
A synthesized peptide derived from human NT5C1A, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NT5C2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NT5C3, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human NT5C, corresponding to a region within C-terminal amino acids.
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