A synthesized peptide derived from human p40, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human p40 phox, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human p40 phox, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human P4HA1, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human P4HA2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from Human P4HA3.
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants.
A synthesized peptide derived from human P4HB, corresponding to a region within C-terminal amino acids.
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
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