Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
A synthesized peptide derived from human APOA5, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human APOB48R, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human APOB, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human APOBEC3A, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human APOBEC3A/B, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human APOBEC3C, corresponding to a region within C-terminal amino acids.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.
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