The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.
A synthesized peptide derived from human XPO4, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human XPO6, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human XPO7.
A synthesized peptide derived from Human XPR1.
Xenotropic mouse leukemia viruses (X-MLVs) are broadly infectious for mammals except most of the classical strains of laboratory mice. These gammaretroviruses rely on the XPR1 receptor for entry, and the unique resistance of laboratory mice is due to two mutations in different putative XPR1extracellular loops. Cells from avian species differ in susceptibility to X-MLVs, and 2 replacement mutations in the virus-resistant chicken XPR1 distinguish it from the more permissive duck and quail receptors.
A synthesized peptide derived from human XRCC1, corresponding to a region within the internal amino acids.
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