A synthesized peptide derived from human ZSCAN4.
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZSWIM1 (zinc finger SWIM domain-containing protein 1), also known as C20orf162, is a 485 amino acid protein that contains one SWIM-type zinc finger. The gene encoding ZSWIM1 maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
A synthesized peptide derived from human ZSWIM3.
A synthesized peptide derived from human ZSWIM6.
A synthesized peptide derived from human ZW10, corresponding to a region within the internal amino acids.
This protein is essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. And it is required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. ZWILCH gene is deleted in a patient suffering from colorectal cancer with chromosomal instability.
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