This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma.
A synthesized peptide derived from human BCL11A, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BCL11B, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BCL2A1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human Bcl-2, corresponding to a region within the internal amino acids.
Mouse monoclonal antibody is prepared by immunizing synthetic peptide coupled to KLH.
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