This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
A synthesized peptide derived from human BCL-3, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human BCL-3, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human Bcl6, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BCL7A, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human BCL7B, corresponding to a region within the internal amino acids.
This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene.
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