This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Aβ derives from APP via proteolytic cleavage by proteases called α-,β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ,while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP),encoded by APP gene which locate on human chromosome 21q,is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth,neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain,kidney,heart and spleen,but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1).
A synthesized peptide derived from human Beta Arrestin 2, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from Human beta Casein.
A synthesized peptide derived from human beta Catenin.
A synthesized peptide derived from human beta Catenin, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human beta Catenin, corresponding to a region within N-terminal amino acids.
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