This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.
TPO Antibody detects endogenous levels of total TPO.
TPOR Antibody detects endogenous levels of total TPOR.
TPP1 Antibody detects endogenous levels of total TPP1.
TPPP2 Antibody detects endogenous levels of TPPP2.
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