Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In addition, FGF-9 may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Basic fibroblast growth factor (bFGF), also known as FGF2, is a member of the fibroblast growth factor (FGF) family. It is a highly specific chemotactic and mitogenic factor for many cell types, appears to be involved in remodeling damaged tissue, such as ulcer healing, vascular repair, traumatic brain injury (TBI). bFGF is a critical component of human embryonic stem cell culture medium. In addition, bFGF protein is a heparin-binding cationic protein involved in a variety of pathological conditions including angiogenesis and solid tumour growth. Thus, bFGF is regarded as a target for cancers chemopreventive and therapeutic strategies.
FGFBP2 (Fibroblast Growth Factor Binding Protein 2), a secreted chaperone, regulates fibroblast growth factors (FGFs)—key signaling molecules critical for tissue repair, angiogenesis, and cell proliferation—by binding specific ligands (e.g., FGF-1, FGF-2) through a conserved domain to enhance their release from extracellular storage or receptor interactions. Primarily expressed in regenerative or metabolically active tissues (e.g., liver, kidney, epithelia), FGFBP2 is tightly controlled under normal conditions but often overexpressed in cancers, where it amplifies FGF-driven tumor progression by promoting angiogenesis, survival, and metastasis, while also being implicated in metabolic disorders and inflammation through potential links to insulin resistance and fibrosis. Though functionally overlapping with its paralog FGFBP1, FGFBP2 exhibits distinct tissue-specific expression and ligand preferences, with ongoing research focused on elucidating its mechanistic roles in FGF signaling and exploring its therapeutic or biomarker potential in cancer and FGF-associated diseases.
Lascia la tua email e seleziona le aree che vuoi seguire per ricevere novita di prodotto, approfondimenti tecnici e promozioni piu pertinenti.
Puoi scegliere le macro-aree Life Science e Diagnostica oppure le singole specializzazioni.
Seleziona uno o piu ambiti di interesse per ricevere comunicazioni piu utili e mirate.
Aggiornamenti su ricerca, strumentazione e applicazioni per il mondo Life Science.
Novita, approfondimenti e promozioni per laboratori diagnostici e flussi operativi.
2025 TEMA Ricerca - All Rights Reserved.
